Cymbalta (duloxetine) is a prescription medication primarily used to treat depression, anxiety, and certain types of chronic pain, such as fibromyalgia and diabetic neuropathy. While taking Cymbalta, it's important to be aware of certain foods and substances that may interact with the medication or worsen its side effects. Here are some foods and substances to consider avoiding or limiting while taking Cymbalta:

Alcohol: Alcohol can increase the risk of drowsiness, dizziness, and impaired judgment, which are common side effects of Cymbalta. It may also increase the risk of liver damage.

Grapefruit and grapefruit juice: Grapefruit and its juice can interfere with the way your body metabolizes certain medications, including Cymbalta. This can result in higher levels of the drug in your bloodstream, potentially leading to an increased risk of side effects.

Caffeine: Caffeine is a stimulant that can exacerbate the nervousness, anxiety, or restlessness that some people may experience as side effects of Cymbalta. If you're sensitive to caffeine, it's a good idea to limit your intake.

High-fat meals: Consuming high-fat meals can slow down the absorption of Cymbalta, potentially delaying its onset of action. It's generally recommended to take Cymbalta with or without food, but consistently taking it with food is a good way to avoid this issue.

Tyramine-rich foods: Tyramine is a naturally occurring compound found in some foods that can interact with certain antidepressant medications, potentially leading to high blood pressure. While the interaction between Cymbalta and tyramine-rich foods is not as well-established as with some other medications, it's advisable to be cautious with foods like aged cheeses, cured meats, and fermented foods.

Excessive salt: Cymbalta may cause water retention in some individuals, so it's a good idea to limit your sodium intake if you notice this side effect.

Medication interactions: Be cautious if you are taking other medications or supplements, as some combinations can have adverse effects or reduce the effectiveness of Cymbalta. Always consult your healthcare provider and inform them about all the medications and supplements you are taking.